In 1799, Napoleon introduced religious freedom in the city of Bern. This marked the beginning of Catholic life after the Reformation. Since the adoption of the Federal Constitution and the election of Bern as the federal city in 1848, more and more Catholics started settling in Bern. They were mainly federal officials from other predominantly Catholic cantons, and diplomats, but also migrants from neighbouring Italy.

During the Kulturkampf (a political conflict between the Catholic Church and the government of Prussia) in the second half of the 19th century, the original first Catholic church, Peter and Paul, was attributed to the Old Catholic Church. Consequently, plans were made for a new Catholic church: the Dreifaltigkeitskirche which was consecrated in 1899.

Nowadays, the Catholic Church of the region of Bern consists of 14 parishes, and various communities and missions speaking different languages. It stands for diversity and, with its social commitment, makes an important contribution to the lives of people in Bern.